Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis.

To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced

Cecal ligation and puncture induced sepsis impairs host defense against <i>Enterococcus faecium</i> peritonitis

Multiresistant and vancomycin resistant Enterococcus faecium (VRE) can cause serious infections in hospitalized patients with various co-morbid diseases. We investigated the course of VRE peritonitis after cecal ligation and puncture (CLP)-induced sepsis and compared this to sham operated mice. Mice were subjected to CLP or sham surgery. Forty-eight hours thereafter four groups were created by subjecting mice to peritoneal injection of either VRE or saline. Mice infected with VRE after CLP were severely impaired in eliminating VRE from the peritoneal cavity and distant body sites. These mice failed to mount an early inflammatory response at the primary site of VRE infection. VRE superinfection did not influence CLP-induced organ damage or polymicrobial bacterial loads. Sublethal polymicrobial sepsis greatly facilitates infection and dissemination of VRE. VRE does not influence the course of CLP-induced sepsi

Some properties of NaBaPO[4]:Eu luminophore surface

There is an increased interest to the compounds of the ABPO[4] type, activated by europium, where A and B are mono- and divalent cations, because of their luminescent properties. In this paper NaBaPO[4]:Eu{2+}phosphors with different europium content were synthesized by SHS method. It is shown that phosphor surface becomes less alkaline (pHiis changes in the interval 10,7-9,5) with an increase in the concentration of an introduced activator (5-12%). Two bands with maxima wavelength of approximately 425 and 490 nm are observed in the luminescent spectra (the positions of maxima differ somewhat in different spectra). The relationship between acid-base and luminescent properties of the investigated phosphor samples is traced

Complement activation and long-term graft function in ABO-incompatible kidney transplantation

BACKGROUND: ABO-incompatible and ABO-compatible kidney transplantation are equivalent in terms of short-term graft and patient survival. This is thought to be the result of ABO-incompatible graft accommodation, which occurs when anti-blood group antibodies re-occur after transplantation but somehow do not yield their detrimental effect. The underlying mechanism is unclear, but one of the hypotheses is that this is the result of complement inhibition. Since virtually all ABO-incompatible graft biopsies are C4d positive, this complement inhibition must occur somewhere in the complement cascade after the formation of C4d has already taken place, but where exactly is unclear. It is also unclear whether complement inhibition is complete. Incomplete accommodation could explain why recent studies have shown that long-term graft function in ABO-incompatible transplantation is somewhat inferior to ABO-compatible kidney transplantation.AIM: To unravel the relationship between pre-transplant anti-ABO antibodies, complement activation, and long-term graft function.METHODS: We included all 27 ABO-incompatible transplantations that were performed between 2008 and 2013 at the Academic Medical Center Amsterdam and the University Medical Center Groningen. For each ABO-incompatible transplantation, we included four ABO-compatible controls matched by age, sex, and transplantation date.RESULTS: Graft and patient survival were not significantly different. The slope of kidney function during five-year follow-up was also not significantly different, but ABO-incompatible recipients did have a lower kidney function at three months (creatinine clearance 58 vs 69 mL/min, P = 0.02, Modification of Diet in Renal Disease 46 vs 52 mL/min/1.73 m2, P = 0.08), due to a high rate of early rejection (33% vs 15%, P = 0.03), mostly T-cell mediated. Pre-transplant anti-ABO IgG titers were positively correlated with C5b-9 staining, which itself was positively correlated with the occurrence of T-cell mediated rejection. This may be the result of concurrent C5a formation, which could function as a costimulatory signal for T-cell activation.CONCLUSION: Co-stimulation of T-cell activation by ongoing complement activation by anti-ABO antibodies may be responsible for an impaired long-term graft function in ABO-incompatible kidney transplantation.</p

Economics handbook

1995 handbook for the faculty of Economic

Haematopoietic stem cell migration to the ischemic damaged kidney is not altered by manipulating the SDF-1/CXCR4-axis

Background. Haematopoietic stem cells (HSC) have been shown to migrate to the ischemic kidney. The factors that regulate the trafficking of HSC to the ischemic damaged kidney are not fully understood. The stromal cell-derived factor-1 (SDF-1)/CXCR4-axis has been identified as the central signalling axis regulating trafficking of HSC to the bone marrow. Therefore, we hypothesized that SDF-1/CXCR4 interactions are implicated in the migration of HSC to the injured kidney

ОПТИМІЗАЦІЯ ВИКОРИСТАННЯ РЕСУРСІВ ВУГЛЕВИДОБУВНИХ ПІДПРИЄМСТВ НА ОСНОВІ ВРАХУВАННЯ ВНУТРІШНІХ ЕНТРОПІЙНИХ ЗВ'ЯЗКІВ

У статті розглядаються питання оцінки ефективності використання внутрішніх ресурсів підприємства з метою гармонізації економічних та екологічних взаємовідносин та розробки ноосферного підходу до розробки родовищ корисних копалин. The article is dealt with some problems of the estimation of an enterprise's internal resources utilization. The main goal of it is coordination of economic and ecological interrelations and development of the noosphere approach to the utilization of natural resources' deposits